回到顶部

【帕金森症的基因思考】Genetic screens provide insight into Parkinson’s disease and other neurodegenerative dise

2019年11月25日 10:00 ~ 2019年11月25日 11:30

收起

活动票种
    付费活动,请选择票种
    展开活动详情
    收起

    泛在计算系统研究中心学术报告会

    报告题目:Genetic screens provide insight into Parkinson’s disease and other neurodegenerative disease mechanisms

    时间:20191125日(周一)上午1000-1130

    地点:计算所446会议室

    报告人:Aaron D. Gitler 教授, Stanford University

    摘要:

    My goal is to discover the cellular and molecular mechanisms by which protein aggregates contribute to neurodegeneration and to harness these mechanisms to devise novel therapeutic strategies. We use the baker’s yeast, Saccharomyces cerevisiae, as a simple, yet powerful model system to study the cell biology underpinning protein-misfolding diseases, which include Alzheimer’s disease, Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). We are focusing on the Parkinson’s disease protein alpha-synuclein and the ALS disease protein TDP-43 and have generated yeast models to define mechanisms by which these proteins cause PD ALS. Because these proteins aggregate and are toxic in yeast, we have used these yeast models to perform high-throughput genomewide modifier screens to discover suppressors and enhancers of toxicity. Launching from the studies in yeast, we have extended our findings into animal models and even recently into human patients. For example, we discovered mutations in one of the human homologs of a hit from our yeast TDP-43 modifier screen in ALS patients. Mutations in this gene are relatively common (~5% of cases) making it one of the most common genetic risk factors for ALS discovered to date. These screens are also providing new and completely unexpected potential drug targets, underscoring the power of such simple model systems to help reveal novel insight into human disease. In our PD studies, we have defined how PD genes and risk factors converge on alpha-synuclein aggregation and prion-like spreading, and validated these findings in mouse neurons, human iPS-derived neurons and in mouse models.

    WechatIMG579.jpeg


    活动嘉宾

    嘉宾头像

    Aaron D. Gitler

    教授

    Stanford University


    举报活动

    活动标签

    最近参与

    • wazte
      报名

      (5年前)

    • 赵和平
      报名

      (5年前)

    • 行者AUV
      收藏

      (5年前)

    • 图云大数据
      收藏

      (5年前)

    • 图云大数据
      报名

      (5年前)

    • 图云高性能
      收藏

      (5年前)

    您还可能感兴趣

    您有任何问题,在这里提问!

    为营造良好网络环境,评价信息将在审核通过后显示,请规范用语。

    全部讨论

    还木有人评论,赶快抢个沙发!

    活动主办方更多

    中科图云

    中科图云

    北京中科图云科技有限公司专注于人工智能/云计算/大数据/高性能方向的技术培训。致力于通过对行业前沿技术的持续创新解读,为相关方向的研究机构和行业用户,提供从训练到推理的一站式人工智能云计算应用服务解决方案/教学实训平台

    微信扫一扫

    分享此活动到朋友圈

    免费发布